Buy Crypto
Markets
Spot
FuturesBTC
Earn
Event Center
Rewards Hub
More

52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are mixed today. The Dow Jones is ⁦-0.46%⁩, the S&P 500 is ⁦+0.32%⁩, and the Nasdaq Composite is ⁦+1.09%⁩. Across individual stocks, 2,308 are advancing while 2,809 are declining, suggesting a mixed market tone.

Dow Jones
51,286.21
Change
-236.85-0.46%
S&P 500
7,376.92
Change
+23.19+0.32%
Nasdaq Composite
24,579.425
Change
+264.428+1.09%
24H Gainers
2,308
24H Losers
2,809

52 Week Gainers

#Stock52 Week Range
4701CollPlant Biotechnologies LtdCLGN$3.94-1.28%29.19K$7.45M$2.64 - $22.500.00%
4702Vestand Inc.VSTD$0.10-44.44%2.05M$0$0.00 - $0.730.00%
4703Context Therapeutics Inc.CNTX$0.19+3.35%1.27M$17.73M$0.19 - $3.620.00%
4704Silo Pharma, Inc.SILO$1.33+3.10%21.15K$2.11M$1.10 - $10.430.00%
4705iTonic Holdings LtdITOC$1.74+6.75%6.04K$11.90M$1.57 - $18.400.00%
4706Eightco Holdings Inc.ORBS$0.74+1.59%6.00M$308.69M$0.57 - $4.670.00%
4707Galaxy Payroll Group LimitedGLXG$0.71+8.76%9.24K$4.54M$0.53 - $4.790.00%
4708Expion Energy, Inc.XPON$2.50-4.95%9.29K$2.53M$2.26 - $19.200.00%
4709SunPower Inc.SPWR$0.28+11.82%2.99M$88.72M$0.20 - $2.050.00%
4710Atossa Therapeutics, Inc.ATOS$2.14+7.54%33.80K$21.36M$1.70 - $14.850.00%
4711PureCycle Technologies, Inc.PCT$1.66-11.70%14.08M$333.70M$1.60 - $14.200.00%
4712Smartbird, Inc.BIRD$1.31+0.38%344.57K$12.20M$1.25 - $24.310.00%
4713Nvni Group LimitedNVNI$0.53-34.28%518.40K$5.32M$0.51 - $4.940.00%
4714Kodiak AI, Inc.KDK$1.27+33.00%14.99M$232.72M$0.95 - $11.350.00%
4715OSR Health, Inc.OSRH$0.12-53.28%22.28M$0$0.07 - $0.900.00%
4716Conexeu Sciences Inc.CNXU$2.25+5.66%124.15K$73.38M$2.07 - $18.790.00%
4717Soluna Holdings, Inc.SLNH$0.52+12.13%7.42M$128.29M$0.45 - $3.450.01%
4718Thryv Holdings, Inc.THRY$1.18-1.68%731.00K$52.22M$1.09 - $7.410.00%
4719Arbor Realty Trust, Inc.ABR$1.60-3.31%6.77M$295.60M$1.58 - $9.660.72%
4720Loop Industries, Inc.LOOP$0.260.00%25.55K$12.69M$0.24 - $1.650.00%
4721Beyond Meat, Inc.BYND$6.04-0.41%1.66M$103.88M$5.77 - $46.800.00%
4722BeneficientBENF$0.72+2.28%64.05K$13.57M$0.50 - $9.960.00%
4723DEFSEC Technologies Inc.DFSC$0.55+6.18%37.90K$2.53M$0.49 - $5.090.00%
4724Lantern Pharma Inc.LTRN$0.57+8.68%100.07K$8.48M$0.47 - $4.340.00%
4725PAVmed Inc.PAVM$1.59-1.60%10.16K$12.75M$1.50 - $28.440.00%
4726Hadron Energy, Inc.HDRN$0.68+0.70%51.97K$48.69M$0.60 - $5.400.00%
4727FuboTV Inc.FUBO$7.61-0.39%1.01M$229.79M$7.44 - $48.960.00%
4728Nyxoah SANYXH$0.84+3.69%257.20K$88.60M$0.79 - $5.920.00%
4729Bone Biologics Corp.BBLG$0.32-5.62%135.37K$1.08M$0.32 - $2.390.00%
4730Scienture Holdings, Inc.SCNX$3.12+0.81%7.59K$5.50M$2.64 - $19.470.00%
4731IQSTEL INC.IQST$0.81+6.34%65.96K$8.84M$0.73 - $5.610.00%
4732BridgeBio Oncology Therapeutics, Inc.BBOT$2.03-6.45%651.01K$186.00M$1.99 - $14.870.00%
4733Elicio Therapeutics, Inc.ELTX$1.51+8.57%718.99K$40.80M$1.26 - $16.000.00%
4734Greenland Mines LtdGRML$3.83+7.56%488.32K$52.40M$2.82 - $27.480.00%
4735TScan Therapeutics, Inc.TCRX$0.19+3.85%275.85K$12.00M$0.17 - $1.470.00%
4736ThredUp Inc.TDUP$1.28-11.72%2.33M$142.20M$1.28 - $8.760.00%
4737High-Trend International GroupHTCO$1.75+31.34%657.24K$12.51M$0.90 - $56.590.00%
4738AMC Robotics CorporationAMCI$1.09-0.91%176.38K$24.75M$1.03 - $15.090.00%
4739Xtend AI Robotics, Inc.XTND$0.99+0.93%1.90M$366.22M$0.80 - $7.150.00%
4740Glass House Brands Inc.GLAS$2.07-6.73%1.86M$194.30M$1.67 - $13.250.00%
4741Cogent Communications Holdings, Inc.CCOI$3.96-15.46%4.66M$203.07M$3.59 - $30.320.16%
4742LASE Corp.LASE$0.53-1.65%1.34M$26.39M$0.38 - $4.490.00%
4743TransCode Therapeutics, Inc.RNAZ$1.48-3.31%12.70K$24.97M$1.47 - $12.600.00%
4744Ensysce Biosciences, Inc.ENSC$0.33-11.05%427.47K$6.38M$0.23 - $2.170.00%
4745ZenaTech, Inc.ZENA$0.64-2.77%2.92M$128.14M$0.58 - $5.170.00%
4746NuScale Power CorporationSMR$5.08+15.33%38.15M$2.08B$4.28 - $37.410.00%
4747Anebulo Pharmaceuticals, Inc.ANEB$0.000.00%0$0$0.00 - $2.510.00%
4748PRF Technologies Ltd.PRFX$0.84-4.96%68.78K$2.56M$0.64 - $7.950.00%
4749Rekor Systems, Inc.REKR$0.34+5.37%1.37M$46.25M$0.22 - $2.350.00%
4750Icon Energy Corp.ICON$1.00-1.96%26.39K$3.21M$0.72 - $6.650.00%

Anthropic (PRE): Win NVIDIA H200

Claim PRE points for guaranteed prizes up to $3K

Anthropic (PRE): Win NVIDIA H200

Trade U.S. stocks Your Way on MEXC

RealStocksTokenized StocksStock Futures
What it isRealStocks — real shares of U.S.-listed companiesBlockchain-based tokens linked to U.S. stocks/ETFsUSDT-margined futures on U.S. stock price movements
OwnershipYes — actual sharesNo — synthetic exposure onlyNo — derivative exposure only
Shareholder rightsYes (e.g. dividends)NoNo
Trading hoursU.S. market sessions (pre-market, regular, after-hours, overnight)24/7Up to 24/7 (supported pairs)
Position typesBuy and holdBuy and holdLong, short, leveraged
Best forLong-term investors seeking ownership and dividend incomeTraders wanting round-the-clock access to stock exposure without holding sharesActive/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
CollPlant Biotechnologies Ltd (CLGN) currently leads with a 52-week gain of 81.93% as of 2026-11-06 22:11 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.